Technical Details of NEXTERION® glass substrates

NEXTERION® takes pride in offering a comprehensive array of options tailored to meet your specific needs. From structuring and bonding techniques to a diverse range of thicknesses and dimensions, our products are designed to provide unparalleled flexibility and customization. Additionally, we offer a variety of coating options to enhance performance and functionality, ensuring that every substrate meets the rigorous demands of your application. Discover the perfect combination of technical excellence and adaptability for your project.

 

High-quality material

The typical glass types used are BOROFLOAT® 33 and D 263® borosilicate glass. If another type of material is required, we are pleased to evaluate a suitable solution for our customers. Our products range in extremely high-quality standards for surface finish, flatness, parallelism and absence of surface defects. All NEXTERION® products are produced in certified cleanroom facilities.

Wide range of thicknesses & dimensions

Our typical thicknesses range from 0.1 mm up to 3.0 mm. In addition to the standard life science geomtries, we offer our customers glass substrates exactly customized to their special application. Custom-sized products can be produced in rectangular, square or round formats.

Structuring, pre-scoring, marking and bonding cababilities

We can offer customers the opportunity to customize their substrates with markings on or within the glass surface. To fulfill the demand of very small substrates, we offer standard-sized substrates pre-scored into the final chip size. With the ability to structure and bond our glass materials we materials, we can even manufacturer glass microfluidic chips. We are pleased to support you with tailor-made solutions.

Diverse coating options

Applying thin-film coatings to glass substrates is one of our core competences. Beside a variety of standard coatings to immobilize biomolecules, the application of custom coatings, organic as well inorganic, can be offered.

Structuring and bonding

SCHOTT MINIFAB has an innovative portfolio of structured glass substrates, produced in-house, that offers highly accurate and versatile features. Using an ultra-short pulse laser technology, structuring design can be tailor to exact specifications.

Also available is a unique pre-scoring process, which enables small chip sizes. Standard sized glass substrates get pre-scored in the required chip size for further processing into a larger format and then separated into the final format at the end of processing chain.

Substrates can be delivered in the pre-scored version and separated for our customers.


General structuring

 Parameters for BOROFLOAT® 33, D 263® *

 Unit

 Value

 Thickness range

 mm

 0.1 - 3.0

 Maximum Format

 mm

 200

 Min. structuring radius

 µm

 150

* Other materials upon request


Pre-Scoring

 Parameters

 Unit

 Value

 Standard formats* 

 Wafer

 mm

 148 x 148

 Microtiter plate

 mm

 110  x 74

 Slide

 mm

 75.6 x 25

 Edge roughness

 Ra

 µm

 < 1

 Min. chip size **

 

 µm

 20 (theoretical)

* Customized formats upon request
** strongly depending on thickness


In addition we offer bonded products combining glass/glass or glass/tape materials used in applications which require a structuring inside the substrate or chip. Bonded substrates are especially interesting for microfluidic applications like NGS, molecular diagnostics and life science research.


Tape Bonding

 Parameters

 Unit

 Value

 Inlet / Outlet hole diameter

 µm

 < 500

 Channel width

 µm

 200

 Channel depth

 µm

 45 - 80

 Distance between sturctures

 µm

 up to 200


Fusin Bonding

Structuring

 Interposer Channel

 Laser-abiated Channel

 

 Unit

 Value

 Unit

 Value

 Inlet / Outlet hole diameter

 mm

 0.5 - 2

 mm

 0.5 - 2

 Taper angle hole

 °

 < 3

 °

 < 3

 Channel width

 µm

 > 500

 µm

 > 20

 Channel depth

 mm

 0.1 - 2.25

 µm

 10 - 100

 Channel length

 mm

 < 130

 mm

 < 42

 Taper angle channel

 °

 < 3

 °

 70

 Distance between sturctures

 mm

 > 1

 µm

 20

 Distance edge to channel

 mm

 > 5

 mm

 > 5

Coating

SCHOTT MINIFAB has in-house capabilities for a variety of functional coatings.

  • Dip coating
  • Chemical vapor deposition (CVD)
  • Sputter deposition
  • Solvent-based reactor method
  • Spin coating

Beside standard functional coatings, scale manufacture of customer-developed coatings can be offered.

The below table provides an overview which of the SCHOTT MINIFAB coatings may be appropriate for your application.


 Probe type  Coating
 Oligonucleotides  Aminosilane | Epoxysilane | 3-D Hydrogel | 3-D Polymer | Poly-L-Lysine
 cDNA / PCR  Aminosilane | Epoxysilane | Aldehydesilane| Poly-L-Lysine
 Peptides  Epoxysilane | Aldehydesilane
 Proteins  3-D Hydrogel | 3-D Polymer 
 Antibodies  Epoxysilane | Aldehydesilane | 3-D Hydrogel | 3-D Polymer
 Glycans  3-D Hydrogel | 3-D Polymer
 Cells / Tissues  Depending on type of cell / tissue, please contact us for support and free-of-charge evaluation samples
 Biotin modified molecules  Streptavidin
 Bacterial artificial chromosomes (BAC)  Aminosilane | Epoxysilane | Aldehydesilane | Poly-L-Lysine
 P1 artificial chromosomes (PAC)  Aminosilane | Epoxysilane | Poly-L-Lysine
 Yeast artificial chromosomes (YAC)  Aminosilane | Epoxysilane | Aldehydesilane | Poly-L-Lysine

SCHOTT MINIFAB also offers microarray printing expertise.


Learn more

Material and dimensions

Comparison of SCHOTT MINIFAB standard glass substrate properties:

Property

Unit

BOROFLOAT® 33

D 263®

Mechanical propertiy

Density (annealed at 40 °C/h)

ρ

g/cm3

2,20

2.51

Thermal properties

Cofficient of thermal expansion

CTE α (20-300 °C)

10-6/K

3,25

7.20

 Transformation temperature

Tg

°C

525

557

Optical properties

Refractive index (thickness = 0.70 mm)

րe

-

1.47311

1.5255

րd

-

1.47140

1.5231

Abbe value

νe

 

55

55

Dispersion

րFC

10-4

71,9

96,0

Transmittance (thickness = 0.30 mm)

τ (λ254)

%

< 0.1

< 0.1

τ (λ380)

%

91.2

91.2

τ (λ632.8)

%

92.0

92.0

τ (λ1064)

%

92.0

92.0

Luminous transmittance (thickness = 1.1 mm)

τ(λvD65)

%

92.7

91.7

Stress optical coefficient

C

1.02·10-12 m2/N

4.0

3.4

Chemical properties

Hydrolytic resistance (DIN ISO 719)

Class HGB 1
Equivalent of alkali per gram glass grains

 

 

 

Acid resistance (DIN 12116)

Class S 4
Half surface weight loss after 6 hours

 

 

 

Alkali resistance (DIN ISO 695)

Class A 3
Surface weight loss after 3 hours

 

 

 

The range of glass thicknesses available is very wide depending on the glass type. Typically used glass substrates (BOROFLOAT® 33 and D263®) are borosilicate glass. Other glass types are possible upon request.


Thicknesses and dimensions

 Type

 Product size [mm]

 Thickness [mm]

 Pieces per pack

 Side glass

 75.6 x 25.0

 1.0

 25

 Plate glass

 110.0 x 74.0

 1.0

 5

 Customized dimensions

 up to 200

 0.1 - 3.0

 variable

 

Marking

SCHOTT MINIFAB has in-house capability for laser micromachining of glass. All substrates can be customized with markings including logos, barcodes, fiducial marks and graphics that are robust enough to withstand challenging biomedical laboratory procedures. These markings can be added at any location on or within the glass surface.

Our key capabilities include: laser-induced particle transfer, hydrophobic ink, laser ablation, laser-induced internal marking.

 

 Parameters  Specification
 Barcode type
 Standard  1D: Code 128
 Custom  1D: Code 128 a/b/c; Code 39; 2/5-Family
 2D: QR Code, Data Matrix Code
 Graphics & fiducials  Resolution  127 dpi (binary images)
 Line width  20 µm  (vector format)
 Size max.  40 mm x 40 mm
 Barcode & text  Hight min.  0.12 mm
 2D code min.  1.6 mm (others on request)
 Distance to the edge    min. 1 mm

Want to know more? Let's talk

Whether you need more information, samples, a quote, or advice for a project, I would be delighted to talk to you.

Karola Koban

Karola Koban

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