If you are looking to control your cost-of-goods (COGs) and increase efficiency with high-throughput manufacturing, on-the-fly printing is ideal. We configure your printing deck to ensure mechanical accuracy and dispensing quality in ranges 25µm – 150µm, on substrates and wafers. 
 
For large, high-density arrays with a requirement to print a large number of unique oligos or protein molecules, the time on deck can become extensive with stop-and-drop technology. 

On-the-fly dispensing enables: 

• More efficient printing processes, driving improved product COGS and manufacturing throughput.
• Reduced printing ‘time on deck’,  enabling increased quality due to reduced environmental exposure of both activated substrates and sensitive biomolecules.

Stop-and-drop printing involves dispensing biomolecules with dispense tips in a static mode, followed by lateral movement to the next position. Typically stop-and-drop printing is ideal for larger spot sizes and volume dispense (up to 500 microns), as well as smaller array densities. In addition, stop-and-drop dispensing is optimal for custom sensor designs that require a high level of dispense accuracy on unique features of a biochip. Additional benefits include:

• The ability to accurately spot on chips or sensors that have variable positional tolerances, through the use of sensor pre-imaging,  positional analysis, and program set-up for accurate dispense.
• Stop-and-drop dispense of multiple drops to increase the total volume in any one position while retaining the accuracy of the circularity of the generated spots.

Our proprietary software enables a diverse range of printing configurations which, in combination with a range of glass capillary tips, allow us to spot unique and complex reagents and biomolecules of varying viscosities and spotting buffer formulations. This includes nucleic acids, purified or recombinant proteins, complex antigens, peptides, and cell lysates, as well as inorganic markers or control molecules such as nanoparticles or quantum dots.

Our in-house bioscience team supports microarray development and manufacturing, bringing together molecular entities and biochemical solutions to achieve optimal array functionalization and activity. This includes the precise handling and storage of biomolecules, optimization of spotting buffers for attachment and integrity, and the development of robust blocking, washing, and stabilization processes post-dispense.