SCHOTT TopLine Options for Enhanced Processing

SCHOTT TopLyo^® – Efficient Lyophilization

Due to a need to accelerate time-to-market cycles and increase shelf life stability of biopharmaceuticals, a keen interest in robust and cost-efficient lyophilization has leapt into the limelight. A streamlined lyo cake is crucial for better-automated inspectability – and indeed fundamentally vital to the chief priority ensuring patient safety.

Thanks to their hydrophobic coating, SCHOTT TopLyo^® vials demonstrate less fogging during and less disruption of the lyo cake after the lyophilization process, in addition to reduced residual volumes and higher dosing accuracy after reconstitution.

Properties:

Chemically uniform (Si-O-C-H hydrophobic coating)
Layer thickness: ~40 nm
Non-porous, covalent bond between glass matrix and coating layer
Processability equal to non-coated type I glass vials

Benefits:

Cost reduction due to decreased overfilling – given lower residual volume
Prevention of lyo cake disruption and sidewall fogging for improved automated inspection
Lyo cake stability during transportation
Reduced protein aggregation compared to siliconized vials