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07.02.2018, Mainz, Germany

Perfecting surfaces: SCHOTT enhances production setup for coated vials, doubles capacity

Quartz coatings offer utmost protection for highly sensitive drugs / Hydrophobic layers make lyophilization more efficient / New production setup designed to minimize glass-to-glass contact and particle load
Global pharmaceutical packaging specialist SCHOTT announces its enhanced production setup for coated vials. Due to a growing number of highly sensitive parenteral drugs requiring special packaging solutions, interest in vials with inner coatings is steadily on the rise. To meet this demand, SCHOTT offers vials with a particularly inert inner surface or special surface properties for lyophilization. SCHOTT has over 20 years of coating experience, and this know-how was taken to develop  new coating capabilities. SCHOTT’s new production environment is fully automated, strictly avoids glass-to-glass contact, and focuses on the reduction of particle load.

Creating a chemically stable inner container surface is an ongoing quest for pharmaceutical packaging manufacturers. “Quartz coatings offer a great way to combine well-know, highly processable Borosilicate glass with the pureness of SiO2 (silicon dioxide), creating a very homogeneous surface”, said Florence Buscke, the company’s Global Product Manager for Vials & Coatings. “This enables us to create a functional barrier to minimize drug and container interaction.” SCHOTT Type I plus® vials with a quartz-like inner surface are available in sizes ranging from 2 to 100 milliliters. They ensure that the formulation remains stable over its shelf life by reducing ion leaching and protein adsorption. Furthermore, pharma companies can avoid a pH-shift for unbuffered formulations when using SCHOTT Type I plus®.

Lyophilization is a second area where coated vials can demonstrate a clear advantage. SCHOTT TopLyo® vials are provided with a hydrophobic inner layer. This ensures that liquid residues are drawn together to form larger drops, similar to the so-called lotus effect. The result: a compact and aesthetic lyo cake as well as less fogging at the container walls. As a further advantage, the hydrophobic layer also enables easier emptying and leaves less residual volume after reconstitution, which reduces the need for overfilling. Lastly, SCHOTT TopLyo® vials avoids any residual silicone due to its silicone-free coating technique.

SCHOTT’s high-quality coated vials meet particularly tight dimensional and cosmetic parameters and are 100% camera inspected. The company continues to investment in the development of functional coatings to further enhance its product portfolio.


SCHOTT is a leading international technology group in the areas of specialty glass and glass-ceramics. The company has more than 130 years of outstanding development, materials and technology expertise and offers a broad portfolio of high-quality products and intelligent solutions. SCHOTT is an innovative enabler for many industries, including the home appliance, pharma, electronics, optics, life sciences, automotive and aviation industries. SCHOTT strives to play an important part of everyone’s life and is committed to innovation and sustainable success. The group maintains a global presence with production sites and sales offices in 33 countries. With its workforce of approximately 15,000 employees, sales of 2.05 billion euros were generated in fiscal year 2016/2017. The parent company, SCHOTT AG, has its headquarters in Mainz (Germany) and is solely owned by the Carl Zeiss Foundation. As a foundation company, SCHOTT assumes special responsibility for its employees, society and the environment.
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Joana Kornblum
Public Relations Manager
Hattenbergstraße 10
55122 Mainz
Phone: +49 6131/66-4073