Bioactive Glass

Calcium sodium phosphosilicate is a natural substance that consists only of elements found in the human body, which makes it highly biocompatible. As well as being an environmentally friendly ingredient for cosmetics and cosmeceutical products, it is also entirely vegan.

A natural way to healthier skin

From bone repair to cosmetics

In the late-1960s, ‘45S5-Bioglass’ was developed at the University of Florida as an improved bone implant material to support the regeneration of bone tissue and accelerate the healing process. Today, bioactive glasses are also used in oral care and possess a range of advantages for cosmetics.

The chemical process of bioactivity

In an aqueous environment, rapid ion exchange between the sodium ion of the bioactive glass matrix and the hydrogen ion from the water takes place. The fast release of sodium ions is accompanied by the slower release of bioavailable elements such as calcium ions, silica, and phosphorous.

Absolute skin compatibility

For cosmetics and cosmeceutical products, the unique biocompatibility of bioactive glasses translates to absolute skin compatibility – a property that’s been repeatedly demonstrated by a number of short- and long-term human skin patch tests.

Key cosmetic advantages

Bioactive glass offers a number of benefits, including a reduction of redness from UV treatment, as well as anti-odor properties. In-vivo topometry of human skin also shows a significant reduction in the visibility of wrinkles, while the release of minerals can improve the condition of nails.
Specifications of SCHOTT Vitryxx®


Vitryxx® Bioactive Glass is a fine white powder that is odorless and tasteless. Due to its hydrophilic properties, it must be stored under dry conditions.

Grain Sizes

SCHOTT offers Vitryxx® in the following standard grain size. Customized grain sizes are also available on request.

SM4.0 specified by:
d50: (4.0 ± 1.0) µm
d95: ≤ 20 µm


Chemical Properties

Vitryxx® is composed of four inorganic oxides. Thanks to its inorganic composition, it is able to withstand light and temperature extremes.

Name [mass %]
SiO₂ 45 ± 5
CaO 24.5 ± 3
Na₂O 24.5 ± 3
P₂O₅ 6 ± 2



The melting process is conducted at over 1200°C to eliminate organic impurities left in the material. Strict production procedures are also adhered to in order to minimize the presence of inorganic impurities.The sum of all heavy metal impurities, namely lead (Pb), mercury (Hg), bismuth (Bi), arsenic (As), antimony (Sb), tin (Sn), cadmium (Cd), silver (Ag) and cooper (Cu) is less than 50 ppm. (Pb, Hg, Bi, As, Sb, Sn, Cd, Ag, Cu) < 50 ppm.

Specifications for elements as stated in the cosmetics directive:

Lead (Pb) < 20 ppm
Mercury (Hg) < 5 ppm
Arsenic (As) < 5 ppm
Antimony (Sb) < 5 ppm
Beryllium (Be) < 10 ppm

How SCHOTT Vitryxx® is produced

Cosmetics demand glass particles with high purity levels. SCHOTT adheres to stringent quality requirements throughout manufacture, starting with the raw materials, which have to be free of impurities or discoloring, all the way to the milling process, which must avoid abrasion and contamination with foreign particles.

Next to SCHOTT Vitryxx® and Vitryxx®M Bioactive Glass, further bioactive glass formulations are available upon request.

SCHOTT melts all glasses in specially designed aggregates to produce high quality glass. Different dry and wet grinding technologies are used to grind the raw glass into fine powder depending on the desired grain size and distribution.

Detailed information about powder and particle technology can be found here.

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Whether you need more information, samples, a quote, or advice for a project, I would be delighted to talk to you.

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Antonio Trizzino, Sales Manager Europe
Antonio Trizzino

Sales Manager Europe